If you are working on weight loss, you’ve probably heard about GLP-1 medications like Wegovy. For years, this treatment was available only as a weekly injection. However, as of January 5, 2026, drugmaker Novo Nordisk officially launched the Wegovy daily pill in the U.S.
What Is Wegovy
Wegovy is an FDA approved medication used for chronic weight management. It works by mimicking a natural hormone called GLP-1, which helps regulate appetite, digestion, and blood sugar.
The active ingredient is semaglutide, which mimics the GLP-1 hormone. It works by:
- Regulating appetite: Signaling the brain to feel full.
- Slowing digestion: Keeping food in your stomach longer to extend satisfaction.
- Stabilizing blood sugar: Supporting metabolic health.
Injectable and Oral Pill: What’s the Difference
Both forms of Wegovy contain the same medication. The main differences are how often they are taken and how the body absorbs them.
Key Differences at a Glance
Potential Benefits and Risks
Weight management medications are powerful tools, but they come with side effects that are usually gastrointestinal as the body adjusts. Common issues include:
- Nausea and vomiting
- Diarrhea or constipation
- Abdominal pain or "sulfur burps"
For a deeper dive into managing these symptoms, see our guide on Managing GLP-1 Side Effects.
A Dietitian Perspective
While the "magic" of Wegovy is a reduced appetite, a lower calorie intake puts you at risk for muscle loss. Losing muscle can slow your metabolism and make it harder to maintain your weight later on.
To protect your long-term health while on Wegovy:
- Prioritize Protein: Ensure every meal includes a high-quality protein source to signal your body to keep its muscle.
- Focus on Micronutrients: Since you are eating less, the quality of your food matters more to avoid deficiencies.
- Strength Train: Resistance exercise is the best way to ensure the weight you lose comes from fat, not muscle.
For specific meal planning tips, read GLP-1 and Nutrition: Breaking Down Macros and Micronutrients.
Questions for Your Care Team
If you’re considering Wegovy, bring these questions to your next appointment:
- Based on my morning routine, is the daily pill or weekly injection more sustainable?
- What is my target daily protein goal to prevent muscle loss?
- How will we monitor my progress beyond just the number on the scale?
Medication is a powerful tool, but your daily habits remain the driver of your health.
