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Ozempic: How to Prevent Weight Rebound

Yiwen Lu, MS, RD
May 28, 2024
June 3, 2024

Ozempic: This medication is a hot topic in the medical community today and for good reason. It's gained popularity not only for its ability to improve blood sugar numbers , but also for its effect on weight loss. However, research suggests that gaining back weight you previously lost is common after stopping the medication. In this article, we’ll look into why you might regain that weight back and how to prevent it from happening.

Understanding Ozempic and GLP1 Receptor Agonists

Before we discuss why weight regain is common, let's get a better understanding of how Ozempic works. Ozempic, along with other GLP1 receptor agonists, such as Victoza and Trulicity, function by mimicking the action of the naturally occurring hormone GLP1 (glucagon-like peptide 1). These medications primarily work by stimulating insulin secretion in response to elevated blood sugar levels. This in turn reduces appetite and promotes a sense of fullness. As a result of its hunger suppression abilities, weight loss becomes an additional benefit.

Will I Gain Weight After Stopping Ozempic?

A common question that users of Ozempic ask is, “Will I regain the weight if I discontinue Ozempic or other GLP1 agonists?” The quick answer is yes, if you do not sustain a healthy lifestyle. Ozempic is ideally meant to be taken long-term. However, various factors such as side effects, cost, and accessibility may lead to discontinuation. Studies have found that patients who stop taking drugs like Ozempic for weight loss will, on average, gain back an alarming two-thirds of the weight they lost. This is especially true if healthy lifestyle habits are not maintained. 

The Importance of Lifestyle Modifications

Just as stopping insulin might cause a spike in a person’s blood sugar levels or stopping blood pressure medications for hypertension could lead to elevated blood pressure, the same holds for GLP-1 medications. Obesity, like all other chronic conditions, has no "quick fix" or "magic cure." Sustainable weight loss requires more than just medication. Adopting a healthy eating plan rich in fruits, vegetables, whole grains, and lean proteins, coupled with regular physical activity, is key to long-term success.

While no diet can perfectly replicate the biochemical effects of drugs like Ozempic, certain foods can promote prolonged satiety. Foods rich in fiber and protein, such as lean meat, beans, and legumes, take longer to digest. The additional time it takes to process and metabolize these foods is akin to the stomach-emptying delay caused by GLP-1 medications, as a result, individuals feel enhanced feelings of fullness. Moreover, practicing mindful eating—savoring each bite and eating slowly—can aid in recognizing satiety cues. Several pilot studies have shown that mindfulness eating resulted in an average reduction of 0.83 in A1C levels.

Collaborate with Your Healthcare Providers

Before making any changes to your medication regimen, such as starting or stopping Ozempic or other GLP1 agonists, it's vital to collaborate with your doctor. They can provide personalized guidance tailored to your specific health status, medical history, and treatment goals. Moreover, through Unified Care, you have access to a registered dietitian who can help you discover and maintain a sustainable healthy lifestyle.

I often like to compare leading a healthy lifestyle to brushing your teeth. Just as neglecting to brush can lead to tooth decay, neglecting our diet can have negative effects on our overall health. It's not just about consuming calories; we need to prioritize essential nutrients to nourish our bodies and promote overall well-being. By taking care of our bodies, we give ourselves the opportunity to thrive.


While Ozempic and other GLP1 receptor agonists can be beneficial for managing diabetes and facilitating weight loss, it's essential to recognize that they are not standalone solutions. Sustainable weight management involves a holistic personalized approach that includes careful adjustments of medication, diet, physical activity, and lifestyle changes.

To achieve long-term success in managing both weight and diabetes, discuss your concerns and goals with your healthcare providers and dietitians openly. Together, we can develop a tailored plan that fits your needs and promotes overall well-being. Don't hesitate to message your care team anytime if you have additional questions or need further support!

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